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Keep track of Intently (one)mitotane decreases levels of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Mitotane is a strong inducer of cytochrome P-4503A4; check when coadministered with CYP3A4 substrates for feasible dosage adjustments.omaveloxolone will reduce the level or effect of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Omaveloxolone may possibly minimize systemic publicity of delicate CYP3A4 substrates. Look at prescribing facts of substrate if dosage modification is necessary.
Prevent utilization of lorlatinib with CYP3A substrates, where by minimal concentration adjustments may bring about significant therapeutic failures from the substrate. If concomitant use is unavoidable, enhance CYP3A substrate dosage in accordance with authorised product or service labeling.
There aren't any experiments on placental transfer or teratogenicity of The mix of ergotamine and caffeine
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lenacapavir will improve the amount or impact of ergotamine by affecting hepatic enzyme CYP2E1 metabolism. Stay clear of or Use Alternate Drug. Coadministration of lenacapavir with dihydroergotamine, ergotamine or methylergonovine is not encouraged.
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istradefylline will boost the stage or outcome of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
itraconazole will enhance the degree or impact of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Amplified risk of ergotism leading to cerebral ischemia and/or ischemia from the extremities
Check Closely (one)ergotamine will raise the level or influence of midazolam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
ergotamine decreases results of fenfluramine by pharmacodynamic antagonism. Use Warning/Observe. Strong serotonin receptor antagonists may well lessen fenfluramine efficacy.
isavuconazonium sulfate will increase the amount or outcome of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.