Keep track of Intently (one)mitotane decreases levels of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Mitotane is a strong inducer of cytochrome P-4503A4; check when coadministered with CYP3A4 substrates for feasible dosage adjustments.omaveloxolone will reduce the level or effect of ergotamine by impactin… Read More